Compound in Broccoli bound to kill 90% of cavity-causing bacteria

A natural compound produced when eating cruciferous vegetables — such as broccoli, kale, cabbage, and Brussels sprouts — has been found to eliminate nearly 90% of the bacteria responsible for tooth decay, according to new research.

The study, conducted by scientists from Ben-Gurion University of the Negev in collaboration with researchers in Singapore and China, identified the molecule 3,3′-Diindolylmethane (DIM) as the key agent behind the effect.

In laboratory experiments, DIM destroyed about 90% of Streptococcus mutans biofilms, the sticky bacterial layers that cling to tooth enamel and contribute to plaque and cavities. S. mutans produces acids that erode the tooth surface, but DIM appears to interfere with the bacteria’s ability to form and maintain these protective films, effectively breaking down their defenses.

“These results suggest that DIM could be a powerful, natural weapon against tooth decay,” the researchers said, noting that the compound’s anti-biofilm properties might make it suitable for use in toothpaste, mouthwash, or other oral hygiene products.

However, the findings are still preliminary. The experiments were conducted in vitro — in a laboratory setting — and not yet tested in humans. Further research will be needed to determine whether DIM is safe and effective for real-world use.

If confirmed, the discovery could pave the way for a new generation of plant-based dental care products that prevent cavities without relying on harsh chemicals or antibiotics.